Danthiri were a species genetically engineered by the Infinite Empire of the Rakata circa 27,500 BBY. They were created when the Rakata collected a number of species and bred them to be used as weapons. The Danthiri were specifically created to be deployed against the Sith species of Korriban, but the Danthiri rose up against their Rakatan handlers. The Infinite Empire abandoned their research into the Danthiri after the uprising.
The Danthiri became active members of galactic society after their uprising. Thousands of years later, during the Great Hutt Wars, a Danthiri/Human hybrid named Talzea Keldroma became Grand Master of the Jedi Order.